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To assess the association between lower limb fractures and asthma. A 1:1 case-control study in which 28 cases and 56 controls were chosen. The cases consisted of patients aged between five and 15 years old who were admitted to the Pediatric Emergency Department of a children’s hospital in São Paulo, Brazil, with diagnosis of asthma for the first time. The controls were selected from the same Pediatric Emergency Department during the same period of time and were matched with the cases by age, sex, race and hospitalization date. The prevalence of lower limb fractures was 13.3%. The cases were older (10.1 ± 2.8 vs. 7.9 ± 1.9 years; p = 0.003), had a higher prevalence of atopy (61.5 vs. 34.8%; p = 0.01), and were more likely to be breast-fed for at least one month (41.5 vs. 9.1%; p = 0.001) than controls. The use of inhalers was higher among cases than controls (78.6 vs. 42.9%; p = 0.004). The odds ratio for being a case relative to a control was 3.3 (95% confidence interval = 1.6-7.1; p = 0.001), and the odds ratio for being a female relative to a male was 7.1 (95% confidence interval = 2.0-25.5; p = 0.0009). The odds ratio was 6.5 (95% confidence interval = 1.5-28.7; p = 0.01) for exposure to cigarette smoke in the home. The use of inhalers was associated with being a case (odds ratio = 5.4; 95% confidence interval = 1.4-20.4; p = 0.02). A positive association was found between childhood asthma and lower limb fractures.Reduction in mortality from red cell transfusion: a literature review.
We conducted a comprehensive literature review of transfusion-related mortality and morbidity, using Medline, Embase, CancerLit and International Development Gateway as well as the Cochrane Library in 2004. Of 1,937 studies, 17 were included. The transfusion-transmitted infections with greatest evidence were hepatitis, tuberculosis, and HIV. Blood transfusion remains the most important exposure
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